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1 And there's some evidence linking the use of prescription drugs — such as thalidomide and valproic acid — during pregnancy with a higher risk of ASDs.
2 Valproic acid (VPA) is often used to treat seizure disorder and mania as a mood stabilizer.
3 AED is increasingly being used to prevent migraine headaches, double-blind controlled studies suggest that valproic acid (VPA) or double valproic acid, TPM, GBP had a good effect on migraine.
4 Valproic acid (VPA) is a compound of fatty acid and a commonly used anti-epileptic drug.
5 OBJECTIVE To investigate the association between valproic acid (VAP) plasma concentration at steady state (Css) and CYP2C19 gene polymorphisms for better individualized medication.
6 Aim To study the relation between dosage and serum concentration of valproic acid in children with epilepsy.
7 Valproic acid is the first treatment to be evaluated in the network.
8 OBJECTIVE: to observe the factors that influence the fluctuation of serum concentrations of valproic acid and to improve the effectiveness and usefulness of monitoring the serum concentration.
9 METHODS 156 epileptic outpatients received valproic acid as monopharmacy or in combination with either the antiepileptic drug were monitored during their clinical routine care.
10 CONCLUSION Those effects of age, total body weight and combination with either the antiepileptic drug on the rate of valproic acid clearance are obviously.
11 Method: The serum concentration of oral phenytoin, carbamazepine and valproic acid were determined in 26,74 and 144 epileptic patients by fluorescence polarization immunoassay, respectively.
12 Taking L-carnitine supplements may prevent any deficiency and may also reduce the side effects of valproic acid.
13 Conclusion: Patients treated with valproic acid need to pay close attention to the changes of the above biochemical tests index.
14 Risk factors during pregnancy include certain infections, such as rubella, toxins including valproic acid, alcohol, cocaine, pesticides, lead, and air pollution, fetal growth restriction, and autoimmune diseases.
15 Aspirin is known to displace a number of drugs from protein-binding sites in the blood, including the antidiabetic drugs tolbutamide and chlorpropamide, warfarin, methotrexate, phenytoin, probenecid, valproic acid (as well as interfering with beta oxidation, an important part of valproate metabolism), and other NSAIDs.
16 Lithium and the anticonvulsants carbamazepine, lamotrigine, and valproic acid are classed as mood stabilizers due to their effect on the mood states in bipolar disorder.
17 Drugs that are more rapidly metabolized with carbamazepine include warfarin, lamotrigine, phenytoin, theophylline, and valproic acid.
18 Valproic acid and valnoctamide both inhibit microsomal epoxide hydrolase (MEH), the enzyme responsible for the breakdown of carbamazepine-10,11 epoxide into inactive metabolites.
19 By inhibiting MEH, valproic acid and valnoctamide cause a build-up of the active metabolite, prolonging the effects of carbamazepine and delaying its excretion.
20 Conversely, endogeneous GHB production in those taking valproic acid will be inhibited via inhibition of the conversion from succinic acid semialdehyde to GHB.
21 Sophy recommended Busey take valproic acid (Depakote), with which Busey agreed.
22 Histone deacetylase inhibitors in development include valproic acid, vorinostat, belinostat, panobinostat, entinostat, and romidepsin.
23 Valproic acid, a widely prescribed anticonvulsant is a derivative of valeric acid.
24 Valproic acid, one of the most commonly prescribed epilepsy treatment drugs, also used to treat certain psychological conditions such as bipolar disorder, is a known inhibitor of folic acid, and as such, has been shown to cause birth defects, including neural tube defects, plus increased risk for children having cognitive impairment and autism.
25 Valproate (VPA) and its valproic acid, sodium valproate, and valproate semisodium forms are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches.
26 Valproic acid is a branched short-chain fatty acid (SCFA) made from valeric acid.
27 Valproic acid (VPA) is an organic weak acid.
28 A 2016 systematic review compared the efficacy of valproate as an add-on for people with schizophrenia: Based upon five case reports, valproic acid may have efficacy in controlling the symptoms of the dopamine dysregulation syndrome that arise from the treatment of Parkinson's disease with levodopa.
29 Most common adverse effects include: Serious adverse effects include: Valproic acid has a black box warning for hepatotoxicity, pancreatitis, and fetal abnormalities.
30 There is evidence that valproic acid may cause premature growth plate ossification in children and adolescents, resulting in decreased height.